Actor portrayals

NOW APPROVED FOR ATTR‑CM

PROVEN TO HELP PEOPLE
LIVE LONGER

and have fewer heart-related hospital visits*

*Compared to placebo over 3 years. Included hospital stays and urgent visits.
 

Ask your doctor about AMVUTTRA® (vutrisiran)

The first and only silencer for ATTR-CM that works to rapidly knock down TTR at the source†
†Reduced transthyretin (TTR) as early as 6 weeks.
Safety and effectiveness shown in a clinical study of 654 adults with ATTR-CM
4 doses a year given as an injection every 3 months by a healthcare provider
†Reduced transthyretin (TTR) as early as 6 weeks.

Learn more about treatment with AMVUTTRA

Read this brochure for details about how AMVUTTRA works, clinical study results, and more.

Download

Stay informed about ATTR‑CM and AMVUTTRA

Receive emails with the latest information, educational resources, and answers to commonly asked questions. 

Sign up

 

CONNECT WITH A PATIENT EDUCATION LIAISON (PEL)

An Alnylam PEL can provide education to help you better understand ATTR-CM and answer questions about AMVUTTRA.

PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team.

Connect

Alnylam Assist logo

Services and resources designed to help you navigate your treatment journey. Alnylam Assist® offers support with insurance coverage, financial assistance, disease and treatment education, and starting AMVUTTRA.

Learn More

IMPORTANT SAFETY INFORMATION

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause low vitamin A levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.  

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA were pain in the arms or legs, pain in the joints, shortness of breath, and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Indications

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the:

  • cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR‑CM) in adults to reduce heart-related death, hospital stays and urgent visits.
  • polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR‑PN) in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Footer Waves Left Footer Waves Right